Recently, the Tianjin Institute of Industrial Biotechnology (TIIB) of the Chinese Academy of Sciences (CAS), a significant research force in the field of biological manufacturing in the Tianjin Port Free Trade Zone, has achieved another milestone with the completion and launch of its food biological manufacturing knowledge base. Leveraging its accumulated synthetic pathway design methods, TIIB extracted key data from over 5,000 articles over a span of 2 years and analyzed the synthetic pathways of more than 70,000 components through artificial intelligence algorithms, ultimately establishing the food biological manufacturing knowledge base. This knowledge base allows for the inquiry of microbial sources, intrinsic properties, and synthetic routes of different nutrients, providing a reference for the synthesis of nutrients in food. It has been included in the high-quality dataset of the biological manufacturing industry by the National Data Bureau.